Running Mad-ly into mitosis
نویسندگان
چکیده
منابع مشابه
Running Mad-ly into mitosis
control may kick in even before a kinetochore is assembled. The mitotic checkpoint— controlled by Mad1, Mad2, Bub1, BubR1, and Bub3— delays anaphase by inhibiting APC until all kinetochores are properly attached to the spindle. Because inhibition of Mad2 leads to an accelerated mitosis and a precocious anaphase, it has been assumed that the checkpoint itself also regulates mitotic timing. But M...
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The 'mitotic spindle checkpoint' ensures that, before a cell exits from mitosis, all of its chromosomes are aligned on the spindle to form the metaphase plate. Mad2 is an essential component of this checkpoint system and it binds specifically to unattached kinetochores.
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2004
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1663rr5