Ru(II)/Os(II)-based Carbonic Anhydrase Inhibitors as Photodynamic Therapy Photosensitizers for the Treatment of Hypoxic Tumours
نویسندگان
چکیده
Photodynamic therapy (PDT) is a medical technique for the treatment of cancer. It based on use non-toxic molecules, called photosensitizers (PSs), that become toxic when irradiated with...
منابع مشابه
Phenols and Polyphenols as Carbonic Anhydrase Inhibitors.
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Photodynamic therapy (PDT) has been used to treat several types of cancer, and comprises intravascular administration of photosensitizer, uptake by cancer cells, and followed by irradiation of light of appropriate wavelength. Although PDT takes advantage of relative retention of photosensitizer by cancer cells, effective delivery of photosensitizing drugs is of great concern. Several delivery s...
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Carbonic anhydrase (CA) enzymes, specifically membrane-bound isozymes CA IX and CA XII, underpin a pH-regulating system that enables hypoxic tumor cell survival and proliferation. CA IX and XII are implicated as potential targets for the development of new hypoxic cancer therapies. To date, only a few small molecules have been characterized in CA-relevant cell and animal model systems. In this ...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2023
ISSN: ['2041-6520', '2041-6539']
DOI: https://doi.org/10.1039/d3sc03932c