rs629301 CELSR2 polymorphism confers a ten-year equivalent risk of critical stenosis assessed by coronary angiography

Background and aims Novel genetic determinants associated with coronary artery disease (CAD) have been discovered by genome wide association studies. Variants encompassing the CELSR2- PSRC1-SORT1 gene cluster CAD. This study is aimed to investigate rs629301 polymorphism extent of CAD evaluated angiography (CAG), evaluate its associations an extensive panel lipid lipoprotein measurements in a large Italian cohort 2429 patients. Methods results The patients were collected four Intensive Care Units located Palermo Verona (Italy). Clinical Records filed, blood samples collected, lipids apolipoproteins (apo) measured separate laboratories. was defined presence stenotic arteries (>50% lumen diameter) CAG. genotype. Patients 78% 73% (p = 0.007) T/T vs. T/G + G/G genotype carriers respectively. also correlated number arteries, 1.29 (1.04–1.61) risk three-arteries disease. higher levels LDL-, non-HDL cholesterol, apoB, apoE apoCIII, lower HDL-cholesterol. Logistic Regression confirmed that rs629301was independently from common factors, similar conferred ten years age [odds ratios 1.43 (1.04–1.96) 1.39 (1.22–1.58) respectively]. Conclusions allele extension severity positively apoB containing lipoproteins.