Routes and methods of neural stem cells injection in cerebral ischemia

Abstract Cerebral ischemia is a serious cerebrovascular disease with the characteristics of high morbidity, disability, and mortality. Currently, stem cell therapy has been extensively applied to wide range diseases, including neurological disorders, autoimmune deficits, other diseases. Transplantation neural cells (NSCs) very promising treatment method, which not only anti‐inflammatory, antiapoptotic, promoting angiogenesis, neurogenesis effects, but also can improve some side effects related thrombolytic therapy. NSCs could exert protective in alleviating cerebral ischemia‐induced brain damage dysfunctions. However, different injection routes doses determine diverse therapeutic efficacy. This review mainly summarizes various methods ischemia, as well proposes existing problems prospects transplantation.