Route of Infection Influences Zika Virus Shedding in a Guinea Pig Model

Prolonged Shedding of Zika Virus Associated with Congenital Infection.

Panel A shows the clinical timeline of pregnancy and delivery events and examinations, indicating the results of testing of serum, urine, and saliva obtained from the newborn for Zika virus (ZIKV) on quantitative real-time polymerase-chain-reaction (qRT-PCR) assay. Also outlined are the main ZIKV-related events, as shown in color-coded text with respect to the illnesses of the mother and the fa...

Zika Virus Infection after Returning from Thailand

Evolution of H3N2 Influenza Virus in a Guinea Pig Model

Studies of influenza virus evolution under controlled experimental conditions can provide a better understanding of the consequences of evolutionary processes with and without immunological pressure. Characterization of evolved strains assists in the development of predictive algorithms for both the selection of subtypes represented in the seasonal influenza vaccine and the design of novel immu...

Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears.

Zika virus (ZIKV) is an emerging flavivirus that causes congenital abnormalities and Guillain-Barré syndrome. ZIKV infection also results in severe eye disease characterized by optic neuritis, chorioretinal atrophy, and blindness in newborns and conjunctivitis and uveitis in adults. We evaluated ZIKV infection of the eye by using recently developed mouse models of pathogenesis. ZIKV-inoculated ...

Development of a Zika Virus Infection Model in Cynomolgus Macaques

Limited availability of Indian rhesus macaques (IRM) is a bottleneck to study Zika virus (ZIKV) pathogenesis and evaluation of appropriate control measures in non-human primates. To address these issues, we report here the Mauritian cynomolgus macaque (MCM) model for ZIKV infection. In brief, six MCMs (seronegative for Dengue and ZIKV) were subdivided into three cohorts with a male and female e...