Rotenone, Paraquat, and Parkinson’s Disease
نویسندگان
چکیده
منابع مشابه
Rotenone, Paraquat, and Parkinson’s Disease
BACKGROUND Mitochondrial dysfunction and oxidative stress are pathophysiologic mechanisms implicated in experimental models and genetic forms of Parkinson's disease (PD). Certain pesticides may affect these mechanisms, but no pesticide has been definitively associated with PD in humans. OBJECTIVES Our goal was to determine whether pesticides that cause mitochondrial dysfunction or oxidative s...
متن کاملParaquat- and rotenone-induced models of Parkinson's disease.
Parkinson's disease (PD) is a neurodegenerative disorder mainly characterized by a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta. In recent years, several new genes and environmental factors have been implicated in PD, and their impact on DA neuronal cell death is slowly emerging. However, PD etiology remains unknown, whereas its pathogenesis begins to be clarified as ...
متن کاملParaquat neurotoxicity is distinct from that of MPTP and rotenone.
Paraquat, MPTP, and rotenone reproduce features of Parkinson's disease (PD) in experimental animals. The exact mechanisms by which these compounds damage the dopamine system are not firmly established, but selective damage to dopamine neurons and inhibition of complex I are thought to be involved. We and others have previously documented that the toxic metabolite of MPTP, MPP+, is transported i...
متن کاملRotenone and Paraquat Linked to Parkinson’s Disease: Human Exposure Study Supports Years of Animal Studies
A growing body of evidence suggests pesticides may play a role in Parkinson’s disease (PD) in humans. Selfreported PD has been associ ated with lifetime use of pesticides, and animal studies have suggested that the pesticides paraquat and rotenone can cause oxidative stress and mitochondrial dysfunction, respectively—posited mechanisms of action in PD—as well as symptoms in rodents similar to...
متن کاملDifferential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone, and Paraquat on Differentiated SH-SY5Y Cells
Paraquat (PQ), a cationic nonselective bipyridyl herbicide, has been used as neurotoxicant to modulate Parkinson's disease in laboratory settings. Other compounds like rotenone (ROT), a pesticide, and 1-methyl-4-phenylpyridinium ion (MPP(+)) have been widely used as neurotoxicants. We compared the toxicity of these three neurotoxicants using differentiated dopaminergic SH-SY5Y human cells, aimi...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2011
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.1002839