منابع مشابه
Persistence of antibodies to rotavirus in human milk.
Human milk obtained from 21 American nursing mothers was studied for the presence of secretory immunoglobulin A antibody to rotavirus, the most common etiological agent of infantile gastroenteritis. Antibody was quantitated by adaptation of a recently described solid-phase radioimmunoassay technique that employs simian rotavirus as a convenient substitute antigen for human rotavirus. Of the mot...
متن کاملHuman milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis.
Acute gastrointestinal infections due to rotaviruses and other enteric pathogens are major causes of morbidity and mortality in infants and young children throughout the world. Breast-feeding can reduce the rate of serious gastroenteritis in infants; however, the degrees of protection offered against rotavirus infection vary in different populations. The mechanisms associated with milk-mediated...
متن کاملIn Vitro Neutralisation of Rotavirus Infection by Two Broadly Specific Recombinant Monovalent Llama-Derived Antibody Fragments
Rotavirus is the main cause of viral gastroenteritis in young children. Therefore, the development of inexpensive antiviral products for the prevention and/or treatment of rotavirus disease remains a priority. Previously we have shown that a recombinant monovalent antibody fragment (referred to as Anti-Rotavirus Proteins or ARP1) derived from a heavy chain antibody of a llama immunised with rot...
متن کاملAssay of human rotavirus antibody by immune adherence hemagglutination with a cultivable human rotavirus as antigen.
A cultivable human rotavirus, Wa, was propagated in MA-104 cells and used as an antigen in immune adherence hemagglutination (IAHA) and complement fixation (CF) tests. IAHA antibody titers of sera from normal humans were found to be eightfold higher than CF antibody titers. The IAHA antibody determination with the Wa antigen is considered to be especially useful for the seroepidemiological stud...
متن کاملVirus Neutralisation: New Insights from Kinetic Neutralisation Curves
Antibodies binding to the surface of virions can lead to virus neutralisation. Different theories have been proposed to determine the number of antibodies that must bind to a virion for neutralisation. Early models are based on chemical binding kinetics. Applying these models lead to very low estimates of the number of antibodies needed for neutralisation. In contrast, according to the more con...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.6099.1390