Rotational Isomerism in Fluorene Derivatives. X. The Conformational Equilibria of 9-Substituted 9-(2-Methylthiophenyl)- and 9-Substituted 9-(2-Methylsulfinylphenyl)fluorene Derivatives

Synthesis and Antimicrobial Activity of 9-O-Substituted Palmatine Derivatives

A series of new palmatine derivatives with alkyl or alkyl with N-heterocyclic structures were designed and synthesized at C-9-O according to the principle of association. These compounds were characterised by (1)H NMR, (13)C NMR, ESI-MS and elemental analysis, and tested for their antimicrobial activity in vitro to evaluate structure-activity relationships. The results indicated that 9-O-substi...

Conformational Isomerism in l , Substituted Derivatives of 3 , 3 . Dimethylbutane

9-Chloro­methyl-9-[(9H-fluoren-9-yl)meth­yl]-9H-fluorene

In the title compound, C(28)H(21)Cl, the dihedral angle between the two fluorene ring systems is 71.97 (4)°. There is an intra-molecular C-H⋯Cl hydrogen bond. In the crystal structure, the centroid-to-centroid distance between stacked fluorene ring systems is ca 4.22 Å, which indicates that there are no π-π stacking inter-actions between them.

ABSTRACTS IN PERSIAN - Vol. 9, No. 2

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Synthesis, Cytotoxicity and Molecular Docking Studies of the 9-Substituted 5-Styryltetrazolo[1,5-c]quinazoline Derivatives.

In this paper, we describe the synthesis of the 5-styryltetrazolo[1,5-c]quinazolines substituted at the 9-position with a 4-fluorophenyl ring directly or via a conjugated π-spacer (C=C or C≡C bond) based on the 6-bromo-4-chloro-2-styrylquinazoline scaffold. The structures of the synthesized compounds were characterized based on a combination of ¹H-NMR, 13C-NMR, IR and high resolution mass spect...