Rostral Ventrolateral Medulla and Hypertension
نویسندگان
چکیده
منابع مشابه
Pulsatile compression of the rostral ventrolateral medulla in hypertension.
The rostral ventrolateral medulla (RVLM) has been known to be a major regulating center of sympathetic and cardiovascular activities. An association between essential hypertension and neurovascular compression of the RVLM has been reported in clinical observations, including magnetic resonance imaging (MRI) studies. To reconfirm this relationship, we performed MRI using a high-resolution 512 x ...
متن کاملLesions in rostral ventromedial or rostral ventrolateral medulla block neurogenic hypertension.
Neurogenic hypertension results from the removal of inhibitory baroreceptor afferent input to vasomotor systems in the central nervous system. We sought to determine whether the bilateral destruction of neurons in the rostral ventrolateral or rostral ventromedial medulla, made using microinjections of N-methyl-D-aspartic acid (30 nmol in 200 nL), would block the acute increase in arterial press...
متن کاملAngiotensin type 1A receptors on glial cells in rostral ventrolateral medulla and hypertension.
During the 1970s and early 1980s, all the components of the renin–angiotensin system (RAS) were identified within the brain.1 Subsequent physiological studies have shown that angiotensin II (Ang II) can act at various sites within the brain stem and hypothalamus to regulate cardiovascular function and fluid and electrolyte balance. Further, there is increasing evidence that brain Ang II can con...
متن کاملSelective Nrf2 Gene Deletion in the Rostral Ventrolateral Medulla Evokes Hypertension and Sympathoexcitation in Mice.
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcriptional regulator of redox homeostasis that impacts antioxidant gene expression. Central oxidative stress and reduced antioxidant enzyme expression in the rostral ventrolateral medulla (RVLM) contributed to sympathoexcitation in chronic heart failure. In the current study, we hypothesized that deletion of Nrf2 in the RVLM wo...
متن کاملKidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla.
Reactive oxygen species in peripheral cardiovascular tissues are implicated in the pathogenesis of 2 kidney-1 clip hypertension. We recently identified an imbalance between reactive oxygen species generation and oxidant scavenging in the rostral ventrolateral medulla (RVLM) of 2 kidney-1 clip in rats. We tested whether enhanced superoxide signaling in RVLM of 2 kidney-1 clip rats contributes to...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2018
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.118.10921