RORγt-Raftlin1 complex regulates the pathogenicity of Th17 cells and intestinal inflammation.

RORγt and RORα signature genes in human Th17 cells

RORγt and RORα are transcription factors of the RAR-related orphan nuclear receptor (ROR) family. They are expressed in Th17 cells and have been suggested to play a role in Th17 differentiation. Although RORγt signature genes have been characterized in mouse Th17 cells, detailed information on its transcriptional control in human Th17 cells is limited and even less is known about RORα signature...

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway

CD5L/AIM regulates lipid biosythesis and restrains Th17 cell pathogenicity

Chao Wang1, Nir Yosef4,8, Jellert Gaublomme2,3, Chuan Wu1, Youjin Lee1, Clary B. Clish2, Jim Kaminski8, Sheng Xiao1, Gerd Meyer Zu Horste1, Mathias Pawlak1, Yasuhiro Kishi1,9, Nicole Joller1, Katarzyna Karwacz1, Chen Zhu1, Maria Ordovas-Montanes1, Asaf Madi1,2, Ivo Wortman2, Toru Miyazaki6, Raymond A. Sobel5, Hongkun Park2,3, Aviv Regev2,7, and Vijay K. Kuchroo1,2 1Evergrande Center for Immunol...

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

Th17 cells play a critical role in host defense against extracellular pathogens and tissue homeostasis but can induce autoimmunity. The mechanisms implicated in balancing "pathogenic" and "non-pathogenic" Th17 cell states remain largely unknown. We used single-cell RNA-seq to identify CD5L/AIM as a regulator expressed in non-pathogenic, but not in pathogenic Th17 cells. Although CD5L does not a...

Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORγt.

Th17 cells play a significant role in inflammatory and autoimmune responses. Although a number of molecular pathways that contribute to the lineage differentiation of T cells have been discovered, the mechanisms by which lineage commitment occurs are not fully understood. Transcription factors play a key role in driving T cells toward specific lineages. We have identified a role for the transcr...