Root systems analysis branches out

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Root systems analysis branches out

1 Faculty of Biology, Institute of Biology II/Botany, Albert-Ludwigs-University of Freiburg, Freiburg, Germany, 2 Centre of Biological Systems Analysis, Albert-LudwigsUniversity of Freiburg, Freiburg, Germany, 3 Freiburg Institute of Advanced Sciences (FRIAS), Albert-Ludwigs-University of Freiburg, Freiburg, Germany and 4 Centre for Biological Signalling Studies (BIOSS), Albert-Ludwigs-Universi...

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Nedd4 Branches Out

The branching of dendrites and axons is a key determinant of neural circuit formation. In this issue of Neuron, Kawabe et al. demonstrate that the ubiquitin ligase Nedd4 promotes the branching of developing dendrites by targeting the small G protein Rap2. In a complementary study, Drinjakovic et al. show that Nedd4 promotes the branching of developing axons by ubiquitinating a different target,...

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Lamellipodial actin branches out

Many cell types, including fi broblasts and epithelial cells, move forward by forming an actin-rich membrane protrusion, called a lamellipodium, at the front of the cell. In the early 1990s, researchers thought that lamellipodial protrusion was driven by the polymerization of linear actin fi laments. In two JCB papers published in 1997 and 1999, however, Tatyana Svitkina and colleagues revealed...

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Morphogenesis: FGF branches out

Signalling via tissue-specific receptors for fibroblast growth factor is important in tracheal branching and mesodermal patterning in Drosophila; both processes may involve a common primary response - detachment and directed migration of the target cells - that is conserved from worms to mammals.

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Kidney development branches out.

For more than 40 years now, the developing kidney has served as a model paradigm for epithelial-mesenchymal interactions. The principles of inductive signaling, epithelial cell differentiation, and pattern formation are now being addressed with modern genetic and biochemical tools. In addition to the mammalian kidney organ culture model, both zebrafish and Xenopus laevis demonstrate great poten...

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ژورنال

عنوان ژورنال: Molecular Systems Biology

سال: 2013

ISSN: 1744-4292,1744-4292

DOI: 10.1038/msb.2013.51