Romosozumab in postmenopausal women with low bone mineral density

Romosozumab in postmenopausal women with low bone mineral density.

BACKGROUND Sclerostin is an osteocyte-derived inhibitor of osteoblast activity. The monoclonal antibody romosozumab binds to sclerostin and increases bone formation. METHODS In a phase 2, multicenter, international, randomized, placebo-controlled, parallel-group, eight-group study, we evaluated the efficacy and safety of romosozumab over a 12-month period in 419 postmenopausal women, 55 to 85...

Low bone mineral density and fracture burden in postmenopausal women.

BACKGROUND The study objectives were to determine fracture rates in relation to bone mineral density at various central skeletal sites, using the World Health Organization definition for osteoporosis (T-score -2.5 or less), and to contrast fracture patterns among women 50 to 64 years of age with those among women 65 years of age and older. METHODS Historical cohort study with a mean observati...

total duration of breastfeeding is associated with low bone mineral density in iranian postmenopausal women

The Effect of Body Pump Training on Bone Mineral Density and Balance in Postmenopausal Women

Abstract Introduction and aim: Studies has shown that increases bone mineral density (BMD) loss after menopause in women; On the other hand, physical activity is an important factor in preventing osteoporosis and fractures associated with it. The aim of this study was to determine the effects of 6 months low-load very high-repetition resistance training (body pump) on BMD­ and balance in postme...

The effects of transdermal estrogen delivery on bone mineral density in postmenopausal women: A meta-analysis

Background: Due to its minimal systematic adverse effects, transdermal estrogen is widely used for the prevention of osteoporosis in postmenopausal women.The present meta-analysis aimed to clarify the effects of transdermal estrogen on bone mineral density (BMD) of postmenopausal women.Methods: Studies were identified by searching electronic databases including Cochrane Library, MEDLINE, Embase...