Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
نویسندگان
چکیده
Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A contributing factor this resistance presence stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found regulate several key targets that are responsible for stemness, and function oncogenic miRNAs (oncomiRs) or tumor suppressor miRNAs. As a result, alter, be altered by, expression CSC-defining markers their related pathways. These can utilized affect stemness multiple ways, including directly targeting CSCs enhancing efficacy therapeutics. This review highlights current studies regarding roles CSCs, efforts towards development
منابع مشابه
Roles of microRNAs in cancer stem cells.
MicroRNAs are a class of endogenous non-coding RNAs that function as important regulatory molecules via the RNA interference mechanism. Since microRNAs play a fundamental role in regulation of a variety of cellular, physiological, and developmental processes, their aberrant expression can lead to a variety of human diseases including cancer. In particular, microRNAs have been implicated in regu...
متن کاملCancer Stem Cell Plasticity Drives Therapeutic Resistance
The connection between epithelial-mesenchymal (E-M) plasticity and cancer stem cell (CSC) properties has been paradigm-shifting, linking tumor cell invasion and metastasis with therapeutic recurrence. However, despite their importance, the molecular pathways involved in generating invasive, metastatic, and therapy-resistant CSCs remain poorly understood. The enrichment of cells with a mesenchym...
متن کاملNature and Validity of Contracts in Stem Cell Therapeutic Research
One of the most influential scientific approaches in the twentieth century has been discovering stem cells and their therapeutic effectiveness. On the one hand, countless diseases are considered incurable through valid scientific treatments and on the other hand, the hope for new treatments has been considered a promotor of the medical studies in research centers. Throughout such research piece...
متن کاملCancer stem cells: therapeutic targets
Cancer stem cells (CSCs) have been identified as rare cellular populations in many cancers, including leukemia and solid tumors. This minor subpopulation of cancerous cells is immortal tumor-initiating cells which thought to be responsible for cancer initiation, progression, metastasis, recurrence and drug/radiation resistance. Low proliferative rate, high self-renewing capacity, differentiatio...
متن کاملthe survey of the virtual higher education in iran and the ways of its development and improvement
این پژوهش با هدف "بررسی وضعیت موجود آموزش عالی مجازی در ایران و راههای توسعه و ارتقای آن " و با روش توصیفی-تحلیلی و پیمایشی صورت پذیرفته است. بررسی اسنادو مدارک موجود در زمینه آموزش مجازی نشان داد تعداد دانشجویان و مقاطع تحصیلی و رشته محل های دوره های الکترونیکی چندان مطلوب نبوده و از نظر کیفی نیز وضعیت شاخص خدمات آموزشی اساتید و وضعیت شبکه اینترنت در محیط آموزش مجازی نامطلوب است.
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: ['1661-6596', '1422-0067']
DOI: https://doi.org/10.3390/ijms22041624