Roles of M cells in infection and mucosal vaccines
نویسندگان
چکیده
منابع مشابه
Epithelial M Cells: Gateways for Mucosal Infection and Immunization
mucosal and glandular tissues, where they differentiate and Jean-Pierre Kraehenbuhl ‡ into plasma cells. The dimeric or polymeric IgA antibod-*Department of Pediatrics ies thus produced are selectively bound by epithelial Harvard Medical School and GI Cell Biology Laboratory polymeric immunoglobulin receptors, transcytosed Children's Hospital across epithelial cells, and released into glandular...
متن کاملMucosal Immunity and Vaccines
These mucosal surfaces, while located inside the body, are actually a physical barrier between the outside and the sterile interior cavity of the body known as the “systemic” environment. Critical nutrients, oxygen and other molecules are constantly taken up across these mucosal barriers; however, another important function of the mucous is to keep invading pathogens out [15]. Daily these mucou...
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Vaccination is the most successful immunological practice that improves the quality of human life and health. Vaccine materials include antigens of pathogens and adjuvants potentiating the effectiveness of vaccination. Vaccines are categorized using various criteria, including the vaccination material used and the method of administration. Traditionally, vaccines have been injected via needles....
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Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is one of the world's leading infectious causes of morbidity and mortality. As a mucosal-transmitted pathogen, Mtb infects humans and animals mainly through the mucosal tissue of the respiratory tract. Apart from providing a physical barrier against the invasion of pathogen, the major function of the respiratory mucosa ...
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» DCs thus represent an ideal vehicle to be hijacked by HIV to gain transport to T cells. « HIV hijacks the body’s immune system to have itself delivered to T cells in which it can explosively replicate. It does this partly by subverting the function of various types of dendritic cells (DCs) that are present in many of the tissues exposed to the external environment. To date, however, it has be...
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ژورنال
عنوان ژورنال: Human Vaccines & Immunotherapeutics
سال: 2014
ISSN: 2164-5515,2164-554X
DOI: 10.4161/hv.36174