Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells
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چکیده
منابع مشابه
Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells.
We use a novel 3D inter-/intracellular force microscopy technique based on 3D traction force microscopy to measure the cell-cell junctional and intracellular tensions in subconfluent and confluent vascular endothelial cell (EC) monolayers under static and shear flow conditions. We found that z-direction cell-cell junctional tensions are higher in confluent EC monolayers than those in subconflue...
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15 صفحه اولFunctional Roles of Shear Stress in Vascular Endothelial Cells
Endothelial cells play remarkable roles in regulating vascular function in health and disease. Meanwhile, shear stress, which is created due to the friction of the flowing blood on the endothelium of the arterial wall, is critical for vascular homeostasis. Here, the shear stress patterns and its effect on gene expression and vascular function are reviewed.
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The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, depends on complex interactions at the promoter level and utilizes overlapping signal transduction cascades to activate the expression of genes involved in many biological processes.
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Background: Radiation-induced molecular changes on the endothelial surface of brain arteriovenous malformations (AVM) may be used as markers for specific vascular targeting agents. In this study, we examined the level of expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) on brain endothelial cell surface after radiation treatment, with the aim of targeting the radiation-induc...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1207326109