Role of the COP9 Signalosome in Gastrointestinal Cancers
نویسندگان
چکیده
منابع مشابه
The COP9 signalosome
But what does it really do? This is the $64,000 question. If we must join in the rampant speculation, the CSN probably has multiple functions. It may serve as a master dock, bringing together proteins, such as a kinase, its substrate, and the proteasome. The CSN might even be an alternative or additional proteasome lid, shuttling ubiquitinated substrates from the SCF to the proteasome. Alternat...
متن کاملThe COP9 signalosome.
The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a repressor of photomorphogenesis in Arabidopsis, and it has now been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Recently, CSN was revealed to have a metalloprotease activi...
متن کاملThe emerging role of the COP9 signalosome in cancer.
In the last several years, multiple lines of evidence have suggested that the COP9 signalosome (CSN) plays a significant role in the regulation of multiple cancers and could be an attractive target for therapeutic intervention. First, the CSN plays a key role in the regulation of Cullin-containing ubiquitin E3 ligases that are central mediators of a variety of cellular functions essential durin...
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Plants are sessile organisms that have evolved an extraordinary phenotypic and developmental plasticity to optimally adapt to the ambient environment. Light is one of the most critical environmental factors, since it is a key signal for regulating a wide range of developmental and physiological processes. The Constitutively Photomorphogenic9 (COP9) signalosome (CSN), originally discovered as an...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis & Mutagenesis
سال: 2015
ISSN: 2157-2518
DOI: 10.4172/2157-2518.1000210