Role of STAT-1 and STAT-3 in ischaemia/reperfusion injury
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چکیده
منابع مشابه
Activated stat-3 in melanoma.
BACKGROUND Recent studies have demonstrated that the Src-Stat pathway may play an important role in melanoma. We examined the expression of phosphorylated Stat-3 (pStat-3), activated Stat-1 (pStat-1) and interferon alpha receptor subunit 1(IFNAR-1) in human melanocytic neoplasms. METHODS Compound nevi (6), dysplastic nevi (4), congenital nevi (2), primary melanoma (14), and sentinel lymph nod...
متن کاملHepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication.
The hepatitis C virus (HCV) causes chronic hepatitis, which often results in liver cirrhosis and hepatocellular carcinoma. We have previously shown that HCV nonstructural proteins induce activation of STAT-3 via oxidative stress and Ca2+ signaling (G. Gong, G. Waris, R. Tanveer, and A. Siddiqui, Proc. Natl. Acad. Sci. USA 98:9599-9604, 2001). In this study, we focus on the signaling pathway lea...
متن کاملStat 6341 , Statistical Computing Stat 6341 Syllabus STAT 6341
Instructor: Dr. Larry P. Ammann Office hours: MW 2:30-3:30pm, others by appt. Email: [email protected] Office: FO 2.410C Phone: (972) 883-2161 Text: Modern Applied Statistics with S, 4 Ed. Authors: W.N. Venables and B.D. Ripley Additional resources: Matrix Computations Authors: G. Golub and C. van Loan These notes are copyrighted by their author, Larry P. Ammann, and are intended for the use ...
متن کاملInteractions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.
The first STAT-containing transcription factor to be studied, the alpha-interferon-induced ISGF3, is composed of a Stat1:2 heterodimer and a weak DNA-binding protein, p48, that is a member of a growing family of proteins similar to the so-called interferon regulatory factor (IRF-1). The p48 and Stat1:2 heterodimer do not associate stably in the absence of DNA, but we show that amino acids appro...
متن کامل1,4-benzoquinone-induced STAT-3 hypomethylation in AHH-1 cells: Role of oxidative stress
Benzene, a known occupational and environmental contaminant, is associated with increased risk of leukemia. The objectives of this study were to elucidate the regulatory mechanism of the hypomethylated STAT3 involved in benzene toxicity in vitro. As 1,4-benzoquinone (1,4-BQ) is one of benzene's major toxic metabolites, AHH-1 cells were treated by 1,4-BQ for 24 h with or without pretreatment of ...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2004
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2004.tb00476.x