Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury
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چکیده
منابع مشابه
Retinal ganglion cell axonal compression by retinal vessels in light-induced retinal degeneration
PURPOSE To analyze the damage produced by light in mydriatic and miotic albino retinas under two different sources of light. METHODS Albino Sprague Dawley female rats were exposed to 3,000 lx during 48 h under two different light sources: linear and circular bulbs. Before exposure, their left pupils were dilated. Before and at different times after light exposure (ALE), electroretinographic s...
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Glaucoma is a neurodegenerative disease characterized by the apoptotic death of retinal ganglion cells (RGCs). The primary insult to RGCs in glaucoma is thought to occur to their axons as they exit the eye in the optic nerve head. However, pathological signaling pathways that exert central roles in triggering RGC death following axonal injury remain unidentified. It is likely that the first cha...
متن کاملMolecular mechanisms of retinal ganglion cell degeneration in glaucoma and future prospects for cell body and axonal protection
Glaucoma, which affects more than 70 million people worldwide, is a heterogeneous group of disorders with a resultant common denominator; optic neuropathy, eventually leading to irreversible blindness. The clinical manifestations of primary open-angle glaucoma (POAG), the most common subtype of glaucoma, include excavation of the optic disc and progressive loss of visual field. Axonal degenerat...
متن کاملOcular hypertension impairs optic nerve axonal transport leading to progressive retinal ganglion cell degeneration.
Ocular hypertension (OHT) is the main risk factor of glaucoma, a neuropathy leading to blindness. Here we have investigated the effects of laser photocoagulation (LP)-induced OHT, on the survival and retrograde axonal transport (RAT) of adult rat retinal ganglion cells (RGC) from 1 to 12 wks. Active RAT was examined with fluorogold (FG) applied to both superior colliculi (SCi) 1 wk before proce...
متن کاملAltered Transport Velocity of Axonal Mitochondria in Retinal Ganglion Cells After Laser-Induced Axonal Injury In Vitro.
PURPOSE Axonal damage precedes retinal ganglion cell (RGC) apoptosis in glaucomatous optic neuropathy. Because mitochondria in RGC axons are damaged before cell death, we examined axonal mitochondrial transport dynamics after axonal injury. METHODS Mitochondria in rat-cultivated RGCs were stained with rhodamine 123. After axonal injury induced using a laser microdissection system, axonal tran...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2018
ISSN: 0014-4835
DOI: 10.1016/j.exer.2018.03.007