Role of polysialic acid on outgrowth of rat olfactory receptor neurons
نویسندگان
چکیده
منابع مشابه
Role of polysialic acid on outgrowth of rat olfactory receptor neurons
Towards elucidating the role of polysialic acid (PSA) in developing olfactory neuron of the rat, we injected neuraminidase (endo-N) into the olfactory nerve pathway under whole embryo culture, then employed immunohistochemistry to (i) detect expression of highly sialylated neural cell adhesion molecules (NCAM-H) and (ii) identify olfactory neurons via anti-microtubule-associated protein 1B (MAP...
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15 صفحه اولThe Role of Polysialic Acid in Migration of Olfactory Bulb Interneuron Precursors in the Subventricular Zone
Transplantation studies have been used to show that tangential migration of olfactory bulb interneuron precursors is retarded in NCAM-mutant mice, and that this defect reflects loss of NCAM polysialic acid (PSA). In contrast, radial migration of cells within the bulb did not require PSA. Reciprocal transplantations between wild-type and mutant mice have revealed that the mutation affects the in...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 1999
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(99)00092-1