Role of P2Y1 purinoceptor in ADP-induced platelet activation
نویسندگان
چکیده
منابع مشابه
Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP.
OBJECTIVE The platelet ADP receptors P2Y1 and P2Y12 play a pivotal role in platelet aggregation. There is marked interindividual variation in platelet response to ADP. We studied whether genetic variants in the P2Y1 or P2Y12 genes affect platelet response to ADP. METHODS AND RESULTS The P2Y1 and P2Y12 genes were screened for polymorphisms. Associations between selected polymorphisms and the p...
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P2Y1 [P2 (purinergic type-2)-receptor 1] is a G-protein-coupled ADP receptor that regulates platelet activation and ADP-induced Ca2+ signalling. Studies using P2Y1-knockout mice, G(q)-deficient mice or P2Y1-selective inhibitors have previously identified a key role for P2Y1 in pathophysiological thrombus formation at high shear stress. We provide evidence that a positively charged juxtamembrane...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1998
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(98)00025-8