Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
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چکیده
منابع مشابه
The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article
Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle...
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BACKGROUND Cancer cachexia is a complex syndrome associated with multiple metabolic abnormalities. Insulin resistance is present in many cancer patients and may be one mechanism through which muscle wasting occurs. METHODS AND RESULTS The present review examines evidence in support of a role for insulin resistance in the development of muscle wasting during cancer cachexia and identifies area...
متن کاملOxidative stress as a therapeutic target during muscle wasting: considering the complex interactions.
PURPOSE OF REVIEW The aim of this overview is to highlight the multiple ways in which oxidative stress could be exacerbating muscle wasting. Understanding these interactions in vivo will assist in identifying opportunities for more targeted therapies to reduce skeletal muscle wasting. RECENT FINDINGS There are many excellent reviews describing how oxidative stress can damage cellular macromol...
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Myostatin, also known as growth differentiation factor-8 (GDF-8), is a member of the transforming growth factorsuperfamily and was identified in 1997.1 In humans, myostatin is expressed almost exclusively in skeletal muscle and is essential for normal regulation of muscle mass through its actions as a negative regulator of muscle bulk.2 Gene disruption, either natural or by targeted mutation, l...
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Myostatin, also known as growth differentiation factor-8 (GDF-8), is a member of the transforming growth factorsuperfamily and was identified in 1997.1 In humans, myostatin is expressed almost exclusively in skeletal muscle and is essential for normal regulation of muscle mass through its actions as a negative regulator of muscle bulk.2 Gene disruption, either natural or by targeted mutation, l...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2018
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2018/2063179