منابع مشابه
Lipoprotein lipase: regulation and role in lipoprotein metabolism.
Humans and animals deficient in lipoprotein lipase (EC 3.1.1.34; LPL) develop a massive hypertriacylglycerolaemia (Brunzell, 1995). Hence, LPL-mediated hydrolysis of lipoprotein-triacylglycerols is a necessary step in lipoprotein metabolism. The reaction occurs at ‘binding-lipolysis’ sites at the vascular endothelium (Olivecrona & Olivecrona, 1995). Here the enzyme is anchored by interaction wi...
متن کاملChimeras of Hepatic Lipase and Lipoprotein Lipase
Chimeric molecules between human lipoprotein lipase (LPL) and rat hepatic lipase (HL) were used to identify structural elements responsible for functional differences. Based on the close sequence homology with pancreatic lipase, both LPL and HL are believed to have a two-domain structure composed of an aminoterminal (NHz-terminal) domain containing the catalytic Ser-His-Asp triad and a smaller ...
متن کاملActivation of Lipoprotein Lipase
Lipoprotein lipase (LPL) from rat heart acetone powders has been reported to depend on the presence of NH4 + , calcium, or other divalent cations for optimal activity. In addition, the enzyme will not hydrolyze an artificial triglyceride emulsion unless it is converted to an active substrate by the addition of very low density lipoproteins, high density lipoproteins (HDL), or certain peptides c...
متن کاملThe pivotal role of lipoprotein lipase in atherosclerosis.
1 . Introduction acids and 2-monoacylglycerols for tissue utilization [3,4]. Due to the large size of its substrates, the physiological site Atherosclerosis, the underlying cause of heart attacks, of LPL action is at the luminal surface of blood vessels, to stroke and peripheral vascular disease, is responsible for which the enzyme is attached via highly charged heparan over 50% of all deaths i...
متن کاملRole of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy
BACKGROUND A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide conclusive evidence due to compensatory mechanisms that activate endogenous ...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1998
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.26.3_119