Role of Leukotriene Receptor Antagonists in Asthma

Role of leukotriene receptor antagonists in asthma.

Asthma is a chronic inflammatory disease that affects >300 million people worldwide. However, inhaled corticosteroids (ICS), the gold standard therapy for persistent asthma, cannot suppress every component of airway inflammation and often fail to adequately penetrate the small airways in order completely suppress eosinophilia. Cysteinyl leukotrienes are important inflammatory factors that are i...

Leukotriene receptor antagonists: useful in acute asthma?

Beneficial antiinflammatory effects of leukotriene receptor antagonists in asthma.

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The emerging role of leukotriene antagonists in asthma therapy.

T here are two " Sounding Board " articles published in the September 3, 1998, issue of the New England Journal of Medicine that at first glance, do not seem to have much relationship to one another. 1,2 The first article describes ethical guidelines for practicing physicians to prevent financial considerations from interfering with decisions about medical care. The second article reviews the p...

Cysteinyl Leukotriene Receptor Antagonists Decrease Cancer Risk in Asthma Patients

Previous in vitro and in vivo studies have demonstrated the potential of using cysteinyl leukotriene receptor antagonists (LTRAs) for chemoprevention, but this has not been investigated in any clinical setting. We therefore investigated the chemopreventive effect of LTRAs in a nationwide population-based study. From the Taiwan National Health Insurance Research Database, we enrolled adults with...