Role of innate inflammation in traumatic brain injury

Traumatic brain injury is one of the leading causes morbidity and mortality throughout world. Its increasing incidence, in addition to its fundamental role development neurodegenerative disease, proves especially concerning. Despite extensive preclinical clinical studies, researchers have yet identify a safe effective neuroprotective strategy. Following trauma, secondary from molecular, metabolic, cellular changes progressive cerebral tissue damage. Chronic neuroinflammation following traumatic injuries key player injury. Targeting this phenomenon for therapies holds promise. This strategy warrants concrete understanding complex neuroinflammatory mechanisms. In review, we discuss pathophysiological mechanisms such as innate immune response, glial activation, blood-brain barrier disruption, activation mediators, well biological markers We then review existing emerging pharmacological that target improve functional outcome.