Role of Corticotropin-Releasing Factor and Corticosterone in Behavioral Sensitization to Ethanol
نویسندگان
چکیده
منابع مشابه
Role of corticotropin-releasing factor and corticosterone in behavioral sensitization to ethanol.
Neuroadaptations underlying sensitization to drugs of abuse seem to influence compulsive drug pursuit and relapse associated with addiction. Our previous data support a role for the corticotropin-releasing factor (CRF) type-1 receptor (CRF₁) in ethanol (EtOH)-induced psychomotor sensitization. CRF₁ is endogenously activated by CRF and urocortin-1. Because genetic deletion of urocortin-1 did not...
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S ensitization is a ubiquitous biological phenomenon that has a role in the neuroadaptation of many different functions, from learning and memory to stress responsivity. Historically, a specific form of sensitization termed psychomotor sensitization (mistermed in my view as ‘‘behavioral sensitization’’) is induced by repeated administration of drugs of abuse and has been linked to the neuroadap...
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15 صفحه اولA role for corticotropin releasing factor and urocortin in behavioral responses to stressors.
Corticotropin-releasing factor (CRF) and CRF-related neuropeptides have an important role in the central nervous system to mediate behavioral responses to stressors. CRF receptor antagonists are very effective in reversing stress-induced suppression and activation in behavior. An additional CRF-like neuropeptide, urocortin, has been identified in the brain and has a high affinity for the CRF-2 ...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Experimental Therapeutics
سال: 2012
ISSN: 0022-3565,1521-0103
DOI: 10.1124/jpet.111.190595