Role of continuous hypertonic saline in acute ischemic infarcts: a systematic literature review

Continuous hypertonic saline for hemispheric ischemic infarcts has been routinely used in neurocritical centers the management of malignant cerebral edema. However, data supporting its use are extremely limited. We present a systematic literature review that highlights five studies (one randomized control trial and four retrospective cohort) where effects continuous were studied patients with acute infarcts. Collectively, there is lack substantial evidence use. Also, this emphasizes significant study flaws make conclusions largely nongeneralizable. Although reported demonstrate improvement intracranial pressure, no differences neurological or functional outcomes overall mortality. Key Words: Brain edema; Saline solution, hypertonic; Ischemic strokes; Mortality; Critical care