Role of conformational heterogeneity in ligand recognition by viral RNA molecules

نویسندگان

چکیده

Ribonucleic acid (RNA) molecules are known to undergo conformational changes in response various environmental stimuli including temperature, pH, and ligands.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ligand-induced conformational changes observed in single RNA molecules.

We present the first demonstration that fluorescence resonance energy transfer can be used to track the motion of a single molecule undergoing conformational changes. As a model system, the conformational changes of individual three-helix junction RNA molecules induced by the binding of ribosomal protein S15 or Mg(2+) ions were studied by changes in single-molecule fluorescence. The transition ...

متن کامل

Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition.

The role of static structure and conformational flexibility in the recognition of RNA targets by small molecule ligands is discussed with emphasis on the natural aminoglycoside antibiotics and their promiscuity in RNA target binding. A brief overview is given of previous efforts to design simplified aminoglycoside derivatives targeted at the bacterial decoding site RNA.

متن کامل

Small molecules targeting viral RNA.

Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer new opportunities to expand the repertoire of drug targets for the development of antiinfective therapy. Ligands binding to ncRNA architectures are able to affect interactions, structural stability or conformational changes and thereby block processes essential for viral replication. Proof of concept for targ...

متن کامل

How HLA-DM molecules work: recognition of MHC II conformational heterogeneity

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 USA, Graduate Program in Immunology, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ, USA, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, USA, Biophysics Section, Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD...

متن کامل

The role of conformational entropy in molecular recognition by calmodulin

The physical basis for high-affinity interactions involving proteins is complex and potentially involves a range of energetic contributions. Among these are changes in protein conformational entropy, which cannot yet be reliably computed from molecular structures. We have recently used changes in conformational dynamics as a proxy for changes in conformational entropy of calmodulin upon associa...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Physical Chemistry Chemical Physics

سال: 2021

ISSN: ['1463-9076', '1463-9084']

DOI: https://doi.org/10.1039/d1cp00679g