Role of Complement in Chlorpromazine-Induced Phototoxicity
نویسندگان
چکیده
منابع مشابه
Phenothiazine phototoxicity: an experimental study on chlorpromazine and its metabolites.
Chlorpromazine (CPZ) metabolites were studied for their phototoxic potency with the mouse tail technique. The demethylated metabolites were more phototoxic potency with the mouse tail technique. The demethylated metabolites were more phototoxic than CPZ, while CPZ-sulfoxide, 7-hydroxy-CPZ, and 2-chlorphenothiazine were less phototoxic. The phototoxicity of CPZ and desmethyl-CPZ preexposed to UV...
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Background: Hyperprolactinemia is a common side effect of antipsychotic drugs that requires further investigation. The current study was designed to evaluate dose-dependent effect of chlorpromazine (CPZ) on hormonal changes and uterine horn histological structure in rats. Moreover, the mammary glands were analyzed to show hyperprolactinemia-induced histological changes. Methods: Albino Wistar r...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1986
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12284175