Role of Brain Inflammation in Epileptogenesis

Role of Brain Inflammation in Epileptogenesis

Inflammation is known to participate in the mediation of a growing number of acute and chronic neurological disorders. Even so, the involvement of inflammation in the pathogenesis of epilepsy and seizure-induced brain damage has only recently been appreciated. Inflammatory processes, including activation of microglia and astrocytes and production of proinflammatory cytokines and related molecul...

The Role of Brain Inflammation in Epileptogenesis in TSC

The role of inflammation in epileptogenesis.

One compelling challenge in the therapy of epilepsy is to develop anti-epileptogenic drugs with an impact on the disease progression. The search for novel targets has focused recently on brain inflammation since this phenomenon appears to be an integral part of the diseased hyperexcitable brain tissue from which spontaneous and recurrent seizures originate. Although the contribution of specific...

Inflammation independent epileptogenesis in vitro

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CNS Inflammation and Epileptogenesis

An association between acute CNS infections and seizures is reported in the literature. The etiology of these seizures is, in some cases, precipitated by epileptogenic pathogenesis of the infectious agent in the brain parenchyma. A different etiology of seizures as a consequence of infections, independent of the infectious agent, relates to the inflammatory reaction. Thirdly, the febrile respon...