منابع مشابه
In vitro tolerance induction of neonatal murine B cells
The susceptibility of neonatal and adult B lymphocytes to tolerance induction was analyzed by a modification of the in vitro splenic focus technique. This technique permits stimulation of individual hapten-specific clonal precursor cells from both neonatal and adult donors. Neonatal or adult BALB/c spleen cells were adoptively transferred into irradiated, syngeneic, adult recipients which had b...
متن کاملThe role of B cells in the induction of peripheral T cell tolerance.
The immune system of vertebrates is designed to protect against invading pathogens. To be able to deal with different antigenic threats, the T cell repertoire is very diverse. This diversity, though useful, can cause autoimmune diseases if any imbalances in the function of the immune system occur. However, the immune system has its own mechanisms for suppressing or regulating the potentially da...
متن کاملRole of Dendritic Cells in the Induction of Lymphocyte Tolerance
The ability of dendritic cells (DCs) to trigger tolerance or immunity is dictated by the context in which an antigen is encountered. A large body of evidence indicates that antigen presentation by steady-state DCs induces peripheral tolerance through mechanisms such as the secretion of soluble factors, the clonal deletion of autoreactive T cells, and feedback control of regulatory T cells. More...
متن کاملSpecialized role of migratory dendritic cells in peripheral tolerance induction.
Harnessing DCs for immunotherapies in vivo requires the elucidation of the physiological role of distinct DC populations. Migratory DCs traffic from peripheral tissues to draining lymph nodes charged with tissue self antigens. We hypothesized that these DC populations have a specialized role in the maintenance of peripheral tolerance, specifically, to generate suppressive Foxp3+ Tregs. To exami...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Organ Transplantation
سال: 2015
ISSN: 1087-2418
DOI: 10.1097/mot.0000000000000204