Robust inference for the stepped wedge design
نویسندگان
چکیده
منابع مشابه
Comparative evaluation of the stepped wedge design efficiency
The cluster randomised trial (CRT) design is widely used to evaluate interventions targeted at the cluster level and helps alleviate contamination within clusters. CRTs usually require large sample sizes, although matched pair CRTs can limit this problem. The stepped wedge design (SWD) extends CRTs, in cases where it is expected that the intervention will do more good than harm and/or, for logi...
متن کاملThe stepped wedge trial design: a systematic review
BACKGROUND Stepped wedge randomised trial designs involve sequential roll-out of an intervention to participants (individuals or clusters) over a number of time periods. By the end of the study, all participants will have received the intervention, although the order in which participants receive the intervention is determined at random. The design is particularly relevant where it is predicted...
متن کاملDesign and analysis of stepped wedge cluster randomized trials.
Cluster randomized trials (CRT) are often used to evaluate therapies or interventions in situations where individual randomization is not possible or not desirable for logistic, financial or ethical reasons. While a significant and rapidly growing body of literature exists on CRTs utilizing a "parallel" design (i.e. I clusters randomized to each treatment), only a few examples of CRTs using cro...
متن کاملConsidering the design effect for the stepped wedge trial: what can it tell us?
In stepped wedge cluster randomised trials (SWTs) the intervention is rolled out to clusters in a random order. Measurements are collected from different individuals during each step (the time between clusters switching to intervention). It remains unclear how to optimise power in SWTs and the circumstances in which SWTs requires fewer clusters to achieve the same power as parallel cluster rand...
متن کاملBias and inference from misspecified mixed‐effect models in stepped wedge trial analysis
Many stepped wedge trials (SWTs) are analysed by using a mixed-effect model with a random intercept and fixed effects for the intervention and time periods (referred to here as the standard model). However, it is not known whether this model is robust to misspecification. We simulated SWTs with three groups of clusters and two time periods; one group received the intervention during the first p...
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ژورنال
عنوان ژورنال: Biometrics
سال: 2019
ISSN: 0006-341X,1541-0420
DOI: 10.1111/biom.13106