Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies
نویسندگان
چکیده
منابع مشابه
Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies
Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants. It has been shown that most of the variants that were discovered by GWAS could only partially explain disease heritability. The explanation for this missing heritability is generally believed to...
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Genome-wide association studies (GWAS) have identified hundreds of loci at very stringent levels of statistical significance across many different human traits. However, it is now clear that very large samples (n~104-105) are needed to find the majority of genetic variants underlying risk for most human diseases. Therefore, the field has engaged itself in a race to increase study sample sizes w...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0135016