Roads to Dysfunction

The Roads to Mitochondrial Dysfunction

1Department of Chemistry, Postgraduate Program of Chemistry, Federal University of Mato Grosso, 78060-900 Cuiabá, MT, Brazil 2Molecular Pharmacology Research Laboratory, Department of Biotechnology, Periyar University, Salem, India 3Department of Physiology, University of Split School of Medicine, Soltanska 2, 21000 Split, Croatia 4Center for the Study of Chronic Metabolic Diseases, School of S...

Roads to Institutionalization*

The Roads to Mitochondrial Dysfunction in a Rat Model of Posttraumatic Syringomyelia

The pathophysiology of posttraumatic syringomyelia is incompletely understood. We examined whether local ischemia occurs after spinal cord injury. If so, whether it causes neuronal mitochondrial dysfunction and depletion, and subsequent energy metabolism impairment results in cell starvation of energy and even cell death, contributing to the enlargement of the cavity. Local blood flow was measu...

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

BACKGROUND Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson's disease, schizophrenia, depression, autism, and chronic fatigue syndrome. DISCUSSION While the majority of patients with multiple ...

The many roads to tremor.

Tremor represents one of the most prominent examples of aberrant synchronisation within the human motor system, and Essential Tremor (ET) is by far the most common tremor disorder. Yet, even within ET there is considerable variation, and patients may have contrasting amounts of postural and intention tremor. Recently, Pedrosa et al. (2013) challenged tremor circuits in a cohort of patients pres...