RNA vaccines for anti-tumor therapy

encapsulation of gastric tumor lysate in plga nanoparticles as antigen delivery system for anti-tumor vaccines

Therapeutic Anti-Tumor Vaccines: From Tumor Inhibition to Enhancement

Numerous immunization trials have proved successful in preventing the growth of experimental animal tumors and human hepatocarcinomas induced by hepatitis B virus. These results have prompted researchers and physicians to use vaccines in a therapeutic mode but the results have, in general, been disappointing even when strongly immunogenic murine tumors were concerned. Data presented herein sugg...

Anti-idiotypic DNA vaccines for B-cell lymphoma therapy.

The idiotypic determinants expressed by immunoglobulin at the surface of malignant B-cells provide specific targets for vaccination strategies. However, as self-antigens they are poorly immunogenic and vaccines must include carriers to improve immune responses. Chemical cross-linking of purified idiotypic protein is so far the only method which has been employed in clinical trials while a numbe...

RNA N - glycosidase and anti - tumor activities

1. Abstract 2. Introduction 3. Material and methods 3.1. Cloning and sequencing of TYchi gene 3.2. Southern and northern blot hybridization 3.3. Expression and Purification of Recombinant TYchi 3.4. Chitinase enzymic assay of TYchi 3.5. Assay for RNA N-glycosidase activity 3.6. Assay for cell-free translation-inhibiting activity 3.7. Assay for cytotoxic activity on human tumor cells 3.8. Modeli...

Anti-tumor effects of genetic vaccines against HPV major oncogenes

Expression of HPV E5, E6 and E7 oncogenes are likely to overcome the regulation of cell proliferation and to escape immunological control, allowing uncontrolled growth and providing the potential for malignant transformation. Thus, their three oncogenic products may represent ideal target antigens for immunotherapeutic strategies. In previous attempts, we demonstrated that genetic vaccines agai...