منابع مشابه
RNA backbone is rotameric.
Despite the importance of local structural detail to a mechanistic understanding of RNA catalysis and binding functions, RNA backbone conformation has been quite recalcitrant to analysis. There are too many variable torsion angles per residue, and their raw empirical distributions are poorly clustered. This study applies quality-filtering techniques (using resolution, crystallographic B factor,...
متن کاملSemiautomated model building for RNA crystallography using a directed rotameric approach.
Structured RNA molecules play essential roles in a variety of cellular processes; however, crystallographic studies of such RNA molecules present a large number of challenges. One notable complication arises from the low resolutions typical of RNA crystallography, which results in electron density maps that are imprecise and difficult to interpret. This problem is exacerbated by the lack of com...
متن کاملRNA Backbone : Consensus All - angle Conformers and Modular String Nomenclature ( an RNA Ontology Consortium contribution ) Running title - RNA backbone : Consensus conformers & nomenclature
Department of Biochemistry, Duke University Medical Center, Durham NC, 27710-3711, USA Institute of Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Fleming Square 2, CZ-16610 Prague, Czech Republic School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332 School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta...
متن کاملImpact of template backbone heterogeneity on RNA polymerase II transcription
Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution. RNA polymerase II (pol II) governs the transcription of DNA into precursor mRNA in all eukaryotic cells. How pol II recognizes DNA template backbone (phosphodiester linkage...
متن کاملA phylogenetic backbone for Bivalvia: an RNA-seq approach
Bivalves are an ancient and ubiquitous group of aquatic invertebrates with an estimated 10 000-20 000 living species. They are economically significant as a human food source, and ecologically important given their biomass and effects on communities. Their phylogenetic relationships have been studied for decades, and their unparalleled fossil record extends from the Cambrian to the Recent. Neve...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1835769100