Risk of epithelial ovarian cancer <scp>Type I</scp> and <scp>II</scp> after hysterectomy, salpingectomy and tubal ligation—A nationwide case?control study

The proposed different origins and pathways to of the dualistic model epithelial ovarian cancer (EOC) may affect alter potential risk reduction related hysterectomy, salpingectomy tubal ligation. aim our study was analyze associations between or ligation EOC Type I II. In this nationwide register-based case-control study, women diagnosed with EOC, Fallopian tube primary peritoneal 2008 2014 were included. Cases classified into II according histology predefined criteria. exposure variables: identified from national registries. Conditional logistic regression analyses performed evaluate variables. Among 4669 registered cases, 4040 eligible assessed for subtyping resulting in 1033 3007 Ten controls randomly assigned each case register population. analyses, previous had a significantly lower (odds ratio [OR] 0.62; 95% confidence interval [95%CI] 0.45-0.85) but not (OR 1.16; 95%CI 0.75-1.78). Hysterectomy associated reduced both 0.71; 0.52-0.99) 0.81; 0.68-0.96). Similar estimates obtained ligation, although without statistical significance. association supports theory high-grade serous originating fimbriae.