Risk of death in the long QT syndrome when a sibling has died

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Sudden arrhythmia death syndrome: importance of the long QT syndrome.

In approximately 5 percent of sudden cardiac deaths, no demonstrable anatomic abnormality is found. Some cases are caused by sudden arrhythmia death syndrome. A prolonged QT interval is a common thread among the various entities associated with sudden arrhythmia death syndrome. A number of drugs are known to cause QT prolongation (e.g., terfenadine), as are hypokalemia, hypomagnesemia, myocardi...

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Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome.

CONTEXT Analysis of predictors of cardiac events in hereditary long-QT syndrome (LQTS) has primarily considered syncope as the predominant end point. Risk factors specific for aborted cardiac arrest and sudden cardiac death have not been investigated. OBJECTIVE To identify risk factors associated with aborted cardiac arrest and sudden cardiac death during adolescence in patients with clinical...

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KCNE1 and KCNE2 variants in Patients with Long QT Syndrome

Introduction: Long QT syndrome (LQTS) is a type of ventricular arrhythmia characterized by prolonged QT intervals on electrocardiogram or delay in ventricular repolarization and it can lead to syncope, seizure and sudden cardiac death. Here, KCNE1 and KCNE2 variants are studied among Iranian affected families with this syndrome. Materials and Methods: Fifty patients referring to Rajaei Cardiov...

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Long QT molecular autopsy in sudden infant death syndrome

OBJECTIVE To describe experience of long QT (LQT) molecular autopsy in sudden infant death syndrome (SIDS). DESIGN Descriptive audit from two distinct periods: (1) A prospective, population-based series between 2006 and 2008 ('unselected'). (2) Before and after 2006-2008, with testing guided by a cardiac genetic service ('selected'). LQT genes 1, 2, 3, 5, 6 and 7 were sequenced. Next of kin w...

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The Long QT Syndrome

Introduction The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the "primary cardiac arrhythmias" or "cardiac ion channelopathies". The study of inherited LQTS has prov...

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ژورنال

عنوان ژورنال: Heart Rhythm

سال: 2008

ISSN: 1547-5271

DOI: 10.1016/j.hrthm.2008.02.029