Risk Factors For Treatment-Induced Hearing Impairment: Perspective From A Resource-Poor African Setting

Background - Treatment-induced hearing impairment can result from prolonged administration of potentially ototoxic medications often in the pharmacotherapeutic management chronic illnesses such as drug-resistant tuberculosis. Whereas drug ototoxicity may be idiosyncratic, it is imperative to aware its potential risk factors while treating patients. We aimed our study identify risks for patients treated pulmonary tuberculosis at Centre. Patients and methods – This was a 24-month prospective pulmonology unit Federal Medical Centre, Owerri, Nigeria. Each patient had pure tone audiometry before commencement treatment (baseline) after three months comparison. Clinical data obtained using pre-tested examiner-administered questionnaire. Data collected analyzed with SPSS version 25.0 statistical significance set p < 0.05. Results Thirty-eight (38) participants completed male-to-female (M:F) ratio 1.53:1. The modal age group 41-50 years median duration presenting complaints 9.9 weeks. HIV seroprevalence 18.4% among participants. baseline prevalence 73.7% but increased 89.5% cumulative incidence 15.8% which statistically significant (p 0.001). identified were (>50 years), family history impairment, kanamycin BMI <18.5kg/m2 . Conclusion Kanamycin associated more severe than capreomycin. Advancing age, 18.5kg/m2 development setting.