Risk Assessment for Heroin Use and Craving Score Using Polygenic Risk Score

PRSice: Polygenic Risk Score software

SUMMARY A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in un...

Schizophrenia polygenic risk score and psychotic risk detection.

GRACE risk score vs TIMI risk score.

2. Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DEJ, et al. ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: a Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable A...

Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence.

IMPORTANCE Cannabis use during adolescence is known to increase the risk for schizophrenia in men. Sex differences in the dynamics of brain maturation during adolescence may be of particular importance with regard to vulnerability of the male brain to cannabis exposure. OBJECTIVE To evaluate whether the association between cannabis use and cortical maturation in adolescents is moderated by a ...

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

BACKGROUND Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. METHODS AND FINDINGS Using genotype data from 17,008 AD cases and 37,154 controls from the International ...