RIPK1 protects epithelial cells

Tangeretin protects renal tubular epithelial cells against experimental cisplatin toxicity

Objective(s): Cisplatin is an effective antineoplastic agent; its clinical utility, however, is limited by a few salient toxic side effects like nephrotoxicity. This study aimed to determine the potential protective effects of tangeretin, a citrus-derived flavonoid, against renal tubular cell injury in cisplatin-induced renal toxicity of rats.Materials and Methods: Tangeretin was injected intra...

Rac 1 protects epithelial cells against anoikis 1 1 Rac 1 protects epithelial cells against anoikis

RIPK1 protects from TNF-α-mediated liver damage during hepatitis

Cell death of hepatocytes is a prominent characteristic in the pathogenesis of liver disease, while hepatolysis is a starting point of inflammation in hepatitis and loss of hepatic function. However, the precise molecular mechanisms of hepatocyte cell death, the role of the cytokines of hepatic microenvironment and the involvement of intracellular kinases, remain unclear. Tumor necrosis factor ...

Epithelial cells, Exracellular matrix

چکیده‌ مقدمه: ماده‌ خارج‌ سلولی‌ به‌ عنوان‌ بخش مهم‌ ریز محیط‌Microenvironment)‌(، نقش‌ اساسی‌ در نگهداری‌ وضعیت‌ تمایز ‌دارد. در بررسی‌های گذشته، این اثر‌ در برخی سلول‌ها از جمله ‌ سلول‌های‌ پوششی‌ لوله‌ رحم‌ و یا رحم‌ مطالعه شده است. در این پژوهش‌ها‌، برای حفظ‌ تمایز سلول ، علاوه‌ بر ماده ‌خارج‌ سلولی‌ عوامل‌ دیگر‌ی مانند هورمون‌ها، فاکتورهای رشد و سلول‌های داربستی‌ نیز بکار رفته است ولی فر...

Trehalose protects corneal epithelial cells from death by drying.

AIM This study was designed to examine whether trehalose could protect corneal epithelial cells in culture from death by desiccation in order to test trehalose as a potential new eye drop for dry eye syndrome. METHODS Human corneal epithelial cells in near confluent culture in wells of a 96 well multidish were preincubated for 15 minutes with 2, 20, 50, 100, or 200 mM trehalose or maltose in ...