Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes

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Right ventricular hypertrophy and apoptosis after pulmonary artery banding: regulation of PKC isozymes.

OBJECTIVE Pressure overload induced by pulmonary artery banding (PAB) leads to right ventricular (RV) hypertrophy and cardiomyocyte apoptosis. The present study was performed to investigate whether protein kinase C isozymes (PKC-alpha, PKC-betaI, PKC-betaII, PKC-delta and PFC- epsilon ), calcineurin and the renin-angiotensin system (RAS) contribute to PAB-induced cardiac remodeling. METHODS A...

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Pulmonary artery banding for ventricular septal defect.

It is well known that there is a very high mortality in children with ventricular septal defect, who develop heart failure in early infancy (Marquis, 1950; Boesen and Vendel, 1955). Morgan, Griffiths, and Blumenthal (1960) reviewed 125 children up to 14 years of age with ventricular septal defect. Of these, 17 developed heart failure in the first six months of life, 10 dying before their first ...

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Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding.

OBJECTIVE Abrupt increases in right ventricular afterload occur after cardiac transplantation and pulmonary artery banding, which can result in right ventricular hypertrophy and dilatation. Right ventricular dysfunction is also accompanied by beta-adrenergic receptor desensitization. We sought to determine whether selective right ventricular expression of a transgene encoding a beta-adrenergic ...

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Application of centrifugal pump in right ventricular failure due to pulmonary artery hypertension. (A case report)

Background: It has not been yet developed a ost suitable method to treat right ventricular failure due to pulmonar artery hypertention resulted from ventricular arrhythia. Though some case reports about patients ready to heart transplant using left assist device or biventral assist device as bridge have been published in Journals, but nocase concerning application of centrifugal pump for treatm...

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Right and left ventricular function after chronic pulmonary artery banding in rats assessed with biventricular pressure-volume loops.

In many patients with congenital heart disease, the right ventricle (RV) is subjected to abnormal loading conditions. To better understand the state of compensated RV hypertrophy, which could eventually progress to decompensation, we studied the effects of RV pressure overload in rats. In the present study, we report the biventricular adaptation to 6 wk of pulmonary artery banding (PAB). PAB re...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2003

ISSN: 0008-6363

DOI: 10.1016/s0008-6363(03)00470-x