Rickettsial Hemolysis: Effect of Metabolic Inhibitors upon Hemolysis and Adsorption

Rickettsial hemolysis: adsorption of rickettsiae to erythrocytes.

The hemolysis of sheep red blood cells by Rickettsia prowazeki has been characterized. A requirement for the adsorption of the rickettsia to the erythrocyte was indicated. No indication of the production of a soluble hemolysin was observed. Neither adsorption nor hemolysis can proceed at 0 C. The hemolytic process is rapid with a half-time of less than 30 min, and both the rate and extent are p...

Inhibitory and restorative effects of adenine nucleotides on rickettsial adsorption and hemolysis.

The adenine nucleotides, adenosine diphosphate, adenosine triphosphate, (ATP), and the methylene-bridge analogues are inhibitors of rickettsial adsorption to and the hemolysis of sheep erythrocytes. Other nucleotides, adenosine monophosphate, cyclic adenosine monophosphate, cytosine triphosphate, and guanosine triphosphate, are without effect. Adsorption and hemolysis require the generation of ...

Effect of cell shape on extravascular hemolysis.

Although it has been inferred that alteration of erythrocyte shape causes cell clearance. no direct measure of the effect of varying shape on clearance has been made. In this study, the protein oxidant, diamide, was employed to fix rat erythrocytes in altered shapes produced by the addition of different amphipaths or by changes in membrane structure. Clearance of cells in vivo as measured by 51...

Oxidative Hemolysis and Precipitation

The propensity of certain chemicals and drugs to induce hemolytic anemias has been a subject of much interest for almost a century (1-4). The majority of substances so active are aromatic compounds containing amino-, nitro-, or hydroxy groups, although a number of inorganic compounds (e.g., hydroxylamines, nitrates, nitrites and chlorates) are also active (1-4). Such compounds usually cause red...

Bacterial hemagglutination and hemolysis.