Ricin Poisoning
نویسندگان
چکیده
منابع مشابه
Ricin poisoning and forensic toxicology.
Ricin is one of the most fascinating poisons due to its high toxicity: as little as 500 microg can kill an adult. It gained fame by its use in the so-called 'umbrella murder' to kill the Bulgarian dissident Georgi Markov in 1978. Ricin also became known as a potential bio-terror agent to which people could be exposed through the air, food, or water. The origin, biochemistry, toxicity, and analy...
متن کاملPassive and Active Vaccination Strategies to Prevent Ricin Poisoning
Ricin toxin (RT) is derived from castor beans, produced by the plant Ricinus communis. RT and its toxic A chain (RTA) have been used therapeutically to arm ligands that target disease-causing cells. In most cases these ligands are cell-binding monoclonal antibodies (MAbs). These ligand-toxin conjugates or immunotoxins (ITs) have shown success in clinical trials [1]. Ricin is also of concern in ...
متن کاملProteomic Study of Differential Protein Expression in Mouse Lung Tissues after Aerosolized Ricin Poisoning
Ricin is one of the most poisonous natural toxins from plants and is classified as a Class B biological threat pathogen by the Centers for Disease Control and Prevention (CDC) of U.S.A. Ricin exposure can occur through oral or aerosol routes. Ricin poisoning has a rapid onset and a short incubation period. There is no effective treatment for ricin poisoning. In this study, an aerosolized ricin-...
متن کاملAbsorption, Distribution and Pathological Injury in Mice Due to Ricin Poisoning Via the Alimentary Pathway
The aim of this work was to investigate the potential interactions between intestinal absorbance and ricin poisoning. The Caco-2 cell monolayer and everted intestinal sac (VEIS) models were used. The distribution of ricin in CD-1 mice intoxicated with 0.1 mg/kg of ricin intragastrically was determined by immunohistochemistry. The results showed that ricin could not transfer across the healthy C...
متن کاملIsolation of Crystalline Ricin
A toxic crystalline protein has been isolated from crude extracts of castor bean meal. Ultracentrifuge and electrophoresis tests show the crystalline protein to become fairly homogeneous after three or four crystallizations. This is also confirmed by toxicity measurements. Solubility tests, however, indicate the presence of more than one protein component in the crystalline material, possibly i...
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ژورنال
عنوان ژورنال: JAMA
سال: 2005
ISSN: 0098-7484
DOI: 10.1001/jama.294.18.2342