Ribonucleotide Reductase as One Important Target of [Tris(1,10- phenanthroline)lanthanum(III)] Trithiocyanate (KP772)
نویسندگان
چکیده
منابع مشابه
Ribonucleotide Reductase Subunit One as Gene Therapy Target
RNR catalyzes the reaction in which 2 -deoxyribonucleotides are generated from the corresponding ribonucleotide 5 diphosphates. This is the rate-limiting step in the production of 2 -deoxyribonucleoside 5 -triphosphates required for DNA replication. RNR consists of two protein subunits, R1 and R2. The R1 subunit is a Mr 160 KD homodimer that contains the catalytic site, two allosteric effector-...
متن کاملThe Biology Behind Ribonucleotide Reductase Subunit One as Gene Therapy Target
RNR catalyzes the reaction in which 2 -deoxyribonucleotides are generated from the corresponding ribonucleotide 5 diphosphates. This is the rate-limiting step in the production of 2 -deoxyribonucleoside 5 -triphosphates required for DNA replication. RNR consists of two protein subunits, R1 and R2. The R1 subunit is a Mr 160 KD homodimer that contains the catalytic site, two allosteric effector-...
متن کاملRibonucleotide reductase as a target to control apicomplexan diseases.
Malaria is caused by species in the apicomplexan genus Plasmodium, which infect hundreds of millions of people each year and kill close to one million. While malaria is the most notorious of the apicomplexan-caused diseases, other members of eukaryotic phylum Apicomplexa are responsible for additional, albeit less well-known, diseases in humans, economically important livestock, and a variety o...
متن کاملRibonucleotide reductase inhibitors as anti-herpes agents.
Ribonucleotide reductases (RNRs) supply the 2'-deoxyribonucleotide building blocks for DNA synthesis in mammalian cells and for herpes viruses. The viral-encoded RNRs have unique protein sequences that differ from mammalian enzyme primary structures. Selective inhibition of a viral RNR might provide an approach to new anti-herpes agents with minimal effects on the mammalian host RNRs. This revi...
متن کاملGene expression signature based screening identifies ribonucleotide reductase as a candidate therapeutic target in Ewing sarcoma
There is a critical need in cancer therapeutics to identify targeted therapies that will improve outcomes and decrease toxicities compared to conventional, cytotoxic chemotherapy. Ewing sarcoma is a highly aggressive bone and soft tissue cancer that is caused by the EWS-FLI1 fusion protein. Although EWS-FLI1 is specific for cancer cells, and required for tumorigenesis, directly targeting this t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Cancer Drug Targets
سال: 2009
ISSN: 1568-0096
DOI: 10.2174/156800909789056962