Rhythmomimetic Drug Delivery: Modeling, Analysis, and Numerical Simulation

Rhythmomimetic Drug Delivery: Modeling, Analysis, and Numerical Simulation

We develop, analyse and numerically simulate a model of a prototype, glucose-driven, rhythmic drug delivery device, aimed at hormone therapies, and based on chemomechanical interaction in a polyelectrolyte gel membrane. The pH-driven interactions trigger volume phase transitions between the swollen and collapsed states of the gel. For a robust set of material parameters, we find a class of solu...

Turbulence: Numerical Analysis, Modeling, and Simulation

Numerical Simulation of Fluid Flow over a Ceramic Nanoparticle in Drug Delivery System

In this work, for better understanding of drug delivery systems, blood flow over a ceramic nanoparticle is investigated through microvessels. Drug is considered as a nanoparticle coated with the rigid ceramic. Due to the low characteristic size in the microvessel, the fluid flow is not continuum and the no-slip boundary condition cannot be applied. To solve this problem lattice Boltzmann method...

Mathematical Modeling and Simulation of Intravascular Drug Delivery from Drug-Eluting Stents with Biodegradable PLGA Coating

Drug-eluting stents (DES) are commonly used in coronary angioplasty procedures. A DES elutes drug compounds from a thin polymeric coating into the surrounding coronary artery tissue to reduce in-stent restenosis (a significant lumen loss due to growth of vascular tissue). Biodurable (non-erodible) polymers are often used in the current DES coatings, which stay permanently in the patients. While...

Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation.

This review discusses current progress and future challenges in the numerical modeling of targeted drug delivery using functionalized nanocarriers (NC). Antibody coated nanocarriers of various size and shapes, also called functionalized nanocarriers, are designed to be injected in the vasculature, whereby they undergo translational and rotational motion governed by hydrodynamic interaction with...