Rho family GTPases: Making it to the third dimension

Rho family GTPases.

Rho GTPases comprise a family of molecular switches that control signal transduction pathways in eukaryotic cells. A conformational change induced upon binding GTP promotes an interaction with target (effector) proteins to generate a cellular response. A highly conserved function of Rho GTPases from yeast to humans is to control the actin cytoskeleton, although, in addition, they promote a wide...

SnapShot: Rho Family GTPases

Rho RhoA (RHOA) Plasma membrane (PM) and cytosol/­ geranylgeranylation (GG), phosphorylation (PH), ubiquitination (Ub)

Rho-family GTPases: it's not only Rac and Rho (and I like it).

The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases. To date, 22 human genes encoding at least 25 proteins have been described. The best known 'classical' members are RhoA, Rac1 and Cdc42. Highly related isoforms of these three proteins have not been studied as intensively, in part because it has been assumed that they are functionally identical to their bette...

Ras and Rho GTPases A Family Reunion

Rap1, is required to define the position of the new bud. 1997). In vitro, this interaction is not sufficient to stimulate the GEF activity of Cdc24p, and one functional out-and Molecular Biology University College London come of this interaction in vivo, therefore, is likely to be the localization of Cdc24p to the presumptive bud site London WC1E 6BT United Kingdom (Zheng et al., 1995). In S. p...

Small GTPases of the Rho family and cell transformation.