Rhino-9J (hrrh9J): A New Allele at the Hairless Locus
نویسندگان
چکیده
منابع مشابه
Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster
Hairless (H) is the major antagonist within the Notch signalling pathway of Drosophila melanogaster. By binding to Suppressor of Hairless [Su(H)] and two co-repressors, H induces silencing of Notch target genes in the absence of Notch signals. We have applied genomic engineering to create several new H alleles. To this end the endogenous H locus was replaced with an attP site by homologous reco...
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Cell communication in metazoans requires the highly conserved Notch signaling pathway, which is subjected to strict regulation of both activation and silencing. In Drosophila melanogaster, silencing involves the assembly of a repressor complex by Hairless (H) on Notch target gene promoters. We previously found an in-frame internal ribosome entry site in the full length H transcript resulting in...
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ژورنال
عنوان ژورنال: Veterinary Pathology
سال: 1998
ISSN: 0300-9858,1544-2217
DOI: 10.1177/030098589803500409