Rheumatoid synovial cells in culture produce a growth inhibitor.
نویسندگان
چکیده
منابع مشابه
Rheumatoid synovial cells in culture produce a growth inhibitor.
Cultures of synovial cells obtained at surgery from patients with rheumatoid arthritis produced a protein which inhibits the mitosis of normal rabbit and human synovial cells, and of human lung fibroblasts. This mitotic inhibitory effect can be transferred to rabbit synovial cells by intra-articular injection of the animals with rheumatoid synovial cell cultures.
متن کاملAltered acid hydrolase activities in rheumatoid synovial cells in culture.
EA R o CAL s-ruDis of normal and rheumatoid synovial membranes showed markedly increased acid phosphatase and oxidase activities in the lining cells of the rheumatoid membrane.' Acid phosphatase activity, evident in cytoplasmic granules, serves as a marker for lysosomes-subcellular organelles first described by deDuve and shown to contain numerous hydrolases active at an acid pH.2'3 Homogenates...
متن کاملCartilage Matrix Depletion by Rheumatoid Synovial Cells in Tissue Culture
Articular cartilage fragments were added to monolayer cultures of synovial membrane cells. After 3 wk of incubation, the cartilage fragments were examined histologically for metachromasia and basophilia, and for fluorescent staining using a rabbit antiserum to cartilage protein-polysaccharide. Cartilage incubated with cells derived from rheumatoid synovial membranes showed striking loss of meta...
متن کاملRheumatoid synovial endothelial cells produce macrophage colony-stimulating factor leading to osteoclastogenesis in rheumatoid arthritis.
OBJECTIVES Periarticular osteoporosis and joint destruction are major complications in rheumatoid arthritis (RA), caused by osteoclast-mediated bone resorption. However, the mechanisms of monocyte/osteoclast maturation and role of RA endothelial cells (RAECs) in the control of osteoclastogenesis remain unclear. The present study was designed to determine the most important factors that influenc...
متن کاملCytology of rheumatoid synovial cells in culture. IV. Further investigations of cell lines cocultivated with rheumatoid synovial cells.
A previous report described a cell isolate presumed to have arisen by accidental cocultivation (contamination) of the Chang 'liver' cell line and rheumatoid synovial cells. This cell isolate had the same glucose-6-phosphate dehydrogenase isoenzyme as the Chang cell and also some shared antigens. It clearly differed in its karyotype, its ability to grow in semisolid agar, and in the possession o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1978
ISSN: 0003-4967
DOI: 10.1136/ard.37.2.187