Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade
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چکیده
منابع مشابه
Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2α Signaling Cascade.
Rheb, a ubiquitous small GTPase, is well known to bind and activate mTOR, which augments protein synthesis. Inhibition of protein synthesis is also physiologically regulated. Thus, with cell stress, the unfolded protein response system leads to phosphorylation of the initiation factor eIF2α and arrest of protein synthesis. We now demonstrate a major role for Rheb in inhibiting protein synthesis...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2015
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2015.01.014