Rh(D) alloimmunization without apparent exposure to Rh(D) antigen

[Guideline for prevention of RhD alloimmunization in RhD negative women].

Events following which anti-D immunoglobulin should be given to all RhD negative women with no anti-D antibodies: First trimester indications (50 microg)--termination of pregnancy, spontaneous abortion followed by instrumentation, ectopic pregnancy, chorionic villus sampling, partial molar pregnancy; Second and third trimester indications (100 microg)--amniocentesis, cordocentesis, other invasi...

Molecular RHD screening of RhD negative donors can replace standard serological testing for RhD negative donors.

This work aims to assess the value of a generalized molecular RHD screening strategy which could replace routine serological screening of weak D by indirect antiglobulin test. Three independent studies were performed at the two Blood Transfusion Services Berne and Zurich. Donors investigated were 652 RhD negative, but RhC and/or RhE positive, 17,391 mainly Rhccee, and 8200 with normal RhCcEe ph...

MIESCHER et al RECOMBINANT ANTI-RhD PREVENTS RhD IMMUNIZATION

Variant RHD Types in Brazilians With Discrepancies in RhD Typing.

BACKGROUND The knowledge of D variants in patients and donors is important because anti-D alloimmunization can occur in some but not all individuals who express a variant RHD allele. Serologic distinction of RhD discrepancies is not always straightforward, which makes molecular analysis highly desirable. METHODS A group of 223 subjects, 129 patients, and 94 blood donors was identified and ana...

RF and RHD Research.

Rheumatic heart disease (RHD) remains a major neglected disease of poverty. It affects an estimated 33 million persons—mostly in lowand middle-income countries (LMICs) and in low-resource settings of vulnerable populations in high-income countries [1-3]. Recent advances and improvements in the early detection, evaluation, and treatment of acute group A streptococcal pharyngitis has made the pre...